3‐methylindole as a model of equine obstructive lung disease
- 1 March 1984
- journal article
- research article
- Published by Wiley in Equine Veterinary Journal
- Vol. 16 (2) , 108-112
- https://doi.org/10.1111/j.2042-3306.1984.tb01872.x
Abstract
3-Methylindole was administered orally and i.v. to horses and ponies to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterized by bronchiolitis. Clinical signs developed 48-72 h after dosing and were most severe between days 4 and 10 post-dosing. I.v. administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. The respiratory condition induced by this chemical could become a method for standardization of lung function techniques and interpretation in equine obstructive pulmonary disease.This publication has 8 references indexed in Scilit:
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