Decreased Plasma Pancreatic Polypeptide Levels in Pregnancy*

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Abstract
A crude relaxin preparation was obtained from the basal plate region of elective cesarean section human placentas, as well as normal term placentas. The relaxin isolated has different charge properties by ion exchange chromatography from porcine relaxin, although it is of approximately the same molecular size. The most potent fraction obtained has approximately 0.7% of the immunoactivity of purified porcine relaxin when compared with porcine relaxin in a [radioimmunoassay] based on porcine material, suggesting significant amino acid sequence differences between the putative human relaxin and its porcine counterpart.