The Mechanism of Tachyphylaxis to ICI 74,917 and Disodium Cromoglycate
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 51 (3) , 274-283
- https://doi.org/10.1159/000231602
Abstract
Pre-incubation in vitro of sensitised peritoneal mast cells for 10 min with either ICI 74,917 (10––5 M) or disodium cromoglycate (10––3 M) abolished the ability of either drug to inhibit histamine release when subsequently presented to the cells at the same time as antigen. In the case of disodium cromoglycate, tachyphylaxis was abolished by washing the cells after pre-incubation with the drug. The failure to abolish tachyphylaxis to ICI 74,917 was due to the high pre-incubation concentration employed, as at lower concentrations (10––8 M) tachyphylaxis to ICI 74,917 was readily abolished by washing. Tachyphylaxis to these anti-allergic agents may be related to a physical blocking of drug receptor sites on or in mast cells.Keywords
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