EFFECTS OF ADRENAL CORTICAL COMPOUNDS ON LACTATION1

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Abstract
Previous findings that lactation could not be induced in hypophysectomized guinea pigs by lactogenic hormone alone, but could be initiated if adreno-trophic hormone or adrenal cortical extract were given with the lactogen, were confirmed and extended. Lactation could not be induced in hypophysectomized guinea pigs when desoxycorticosterone acetate was given together with adequate amts. of lactogenic hormone. Lactation could be induced when 17-hydroxy-ll-dehydrocorticosterone was given in such cases with lactogenic hormone. It was suggested in hypophysectomized animals and demonstrated in intact animals, that desoxycorticosterone acetate (3 mg. daily) has a lactation-inhibiting influence. This was probably related to the fact that mammary growth sufficient to permit lactation could be induced by this steroid when it was administered in 2-mg. daily doses.