One and three doses of propranolol a day in hypertension
- 1 January 1980
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 27 (1) , 9-15
- https://doi.org/10.1038/clpt.1980.2
Abstract
In 26 patients with essential hypertension who were on continuous chlorthalidone therapy, 1 and 3 daily doses of propranolol were compared in a crossover study. Plasma propranolol levels and heart rates had larger daily fluctuations on single-dose therapy than on 3 times daily; plasma renin activity was more constant. There was no significant difference in blood pressures. Once-daily propranolol dosage was well tolerated and possibly gave less rise to the troublesome side effect of vivid dreaming.Keywords
This publication has 0 references indexed in Scilit: