Serum Cystatin C Concentration as a Marker of Glomerular Filtration Rate in Patients with Various Renal Diseases.
- 1 January 2002
- journal article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 41 (11) , 931-935
- https://doi.org/10.2169/internalmedicine.41.931
Abstract
Objective The present study was undertaken to evaluate clinical application of serum cystatin C as a new marker of glomerular filtration rate (GFR) in patients with various renal diseases. Patients and Methods A total of 140 patients were enrolled in the study. We measured the serum cystatin C levels and compared them with creatinine clearance (Ccr) and inulin clearance (Cin) as an indicator of GFR. Results There was a significant positive correlation between serum cystatin C and creatinine levels (r=0.928). Serum cystatin C was inversely correlated with creatinine clearance. Moreover, the reciprocal serum cystatin C level was positively correlated with Cin (r=0.882). The receiveroperating characteristic curve of serum cystatin C and creatinine demonstrated that the diagnostic accuracy of the serum cystatin C level is superior to that of creatinine in identifying individuals with reduced GFR. Conclusion These results indicated that measurement of serum cystatin C is useful to estimate GFR, and in particular, to detect a mild reduction of GFR in patients with renal diseases. (Internal Medicine 41: 931-935, 2002)Keywords
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