Influence of Albumin Concentration in the Foetal Circulation on the Placental Transfer of 2,2′,4,4′,5,5′‐Hexachlorobiphenyl in the Guinea‐pig

Publisher Website
Google Scholar
Abstract
Placental transport of 2,2'',4,4'',5,5''-hexachlorobiphenyl [an environmental contaminant] in the guinea pig was studied by perfusion technique. This transfer was rapid when heparinized blood was used as perfusion medium. The same concentration of the chlorobiphenyl in both maternal and fetal compartments was achieved .apprx. 20 min after the start of infusion. When dextran solution or dextran solution with addition of Intralipid to the same concentration as the total lipid concentration in blood were used as perfusion medium, there was no placental transport of the chlorobiphenyl. The placental transport of the chlorobiphenyl was strongly dependent on the albumin concentration but independent of the .gamma.-globulin concentration in the perfusion medium.