Functional Bases for a Central Serotonergic Involvement in Classic Migraine: A Speculative View
- 1 June 1985
- journal article
- review article
- Published by SAGE Publications in Cephalalgia
- Vol. 5 (2) , 69-78
- https://doi.org/10.1046/j.1468-2982.1985.0502069.x
Abstract
The rôle of serotonin (5-HT) in the cerebrovascular bed is the subject of the following review. Cerebral blood vessels are supplied with 5-HT-containing fibres which originate in the raphé nuclei in the brainstem. The activation of this system may result in a constriction of large arteries and a dilatation of arterioles. Intra-arterial administration of 5-HT causes reduction in cerebral blood flow and metabolism provided it bypasses the blood-brain barrier. The findings, marked changes in plasma levels of 5-HT and in cerebral blood flow during a classic migraine attack, are suggestive of an involvement of the 5-HT system.Keywords
This publication has 48 references indexed in Scilit:
- EFFECTS OF 5-HYDROXYTRYPTAMINE ON THE CEREBRAL BLOOD FLOW IN THE DOGActa Neurologica Scandinavica, 2009
- Indoleaminergic mechanisms in brain vessels; Localization, concentration, uptake and in vitro responses of 5-hydroxytryptamineActa Physiologica Scandinavica, 1984
- Central serotonergic nerves project to the pial vessels of the brainNature, 1983
- Changes in regional cerebral blood flow during the course of classic migraine attacksAnnals of Neurology, 1983
- The Effects of Serotonin on Local Cerebral Blood FlowJournal of Cerebral Blood Flow & Metabolism, 1983
- Comparison of the Contraction Produced by Various Tryptamine Analogues on Human Basilar Arterial and Rat Aortic Strips In VitroCephalalgia, 1981
- Cerebral blood flow in rats during physiological and humoral stimuli.Stroke, 1981
- A histochemical and ultrastructural study of serotonin‐containing nerves in cerebral blood vessels of the lampreyThe Anatomical Record, 1980
- ACADEMIC PERFORMANCE AND MENTAL HEALTH, IN UNIVERSITY STUDENTS. A TWO YEAR FOLLOW-UP STUDY OF A SAMPLE OF FIRST-YEAR STUDENTS AT THE UNIVERSITY OF UPPSALA 1968Acta Psychiatrica Scandinavica, 1973
- The Response of Cortical Vessels to Serotonin in Experimental Cerebral InfarctionJournal of Neurosurgery, 1967