Premenstrual Syndrome — Pathophysiologic Considerations

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Abstract
During the past decade premenstrual syndrome has become a well-defined entity.1 The hallmark of the syndrome is the repeated occurrence of behavioral and somatic symptoms severe enough to impair a woman's social and work-related functioning during the luteal phase of the menstrual cycle. On the basis of strict diagnostic criteria, the prevalence of the disorder is estimated to be 2.5 percent among women of reproductive age. No marked racial or ethnic differences in the prevalence of the disorder have been identified.There are several effective treatments for premenstrual syndrome that have largely supplanted older, unproved therapies such as dietary restrictions, . . .