Expression of extracellular matrix in hair follicle mesenchyme in alopecia areata
- 1 December 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 123 (6) , 717-724
- https://doi.org/10.1111/j.1365-2133.1990.tb04188.x
Abstract
Human hair follicle mesenchyme contains a distinctive extracellular matrix which varies in volume and composition in concert with the hair growth cycle. To investigate the possibility that mesenchymal function is disturbed in alopecia areata we have studied the expression of extracellular matrix constituents in scalp biopsies from 14 patients by immunohistochemical staining for basement membrane proteins, proteoglycans and interstitial collagens. The staining patterns in follicles from non-lesional scalp were normal. Miniature anagen follicles from bald patches also showed relatively normal expression of basement membrane proteins and proteoglycans. However, in some large anagen follicles from lesional sites, there was loss of the normal staining pattern for chondroitin-6-sulphate in the dermal papilla. In lesional catagen follicles, the glassy membranes showed marked convolution and thickening. These structures stained strongly for laminin and type IV collagen but only weakly for interstitial collagen.Keywords
This publication has 15 references indexed in Scilit:
- Distribution of Two Basement Membrane Proteoglycans Through Hair Follicle Development and the Hair Growth Cycle in the RatJournal of Investigative Dermatology, 1990
- Chondroitin 6-Sulfate Proteoglycan but not Heparan Sulfate Proteoglycan Is Abnormally Expressed in Skin Basement Membrane From Patients With Dominant and Recessive Dystrophic Epidermolysis BullosaJournal of Investigative Dermatology, 1989
- Altered proteoglycan synthesis disrupts feather pattern formation in chick embryonic skinDevelopmental Biology, 1988
- Chondroitin-6-Sulfate-Containing Proteoglycan: A New Component of Human Skin Dermoepidermal JunctionJournal of Investigative Dermatology, 1988
- HLA-DR Expression by Hair Follicle Keratinocytes in Alopecia Areata: Evidence That it Is Secondary to the Lymphoid InfiltrationJournal of Investigative Dermatology, 1988
- Abnormal Expression of Class I and Class II Major Histocompatibility Antigens in Alopecia Areata: Modulation by Topical Immunotherapy*Journal of Investigative Dermatology, 1987
- Rat Hair Follicle Dermal Papillae Have an Extracellular Matrix Containing Basement Membrane ComponentsJournal of Investigative Dermatology, 1986
- Expression of HLA-DR by Anagen Hair Follicles in Alopecia AreataJournal of Investigative Dermatology, 1985
- Expression of basement membrane components through morphological changes in the hair growth cycleDevelopmental Biology, 1985
- Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissuesNature, 1984