Studies on Some Radiation-Induced Chromosome Aberrations in Man

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Abstract
The frequency and type of chromosome aberrations induced by ionizing radiations in human peripheral blood were investigated using usual culture technique. Irradiated persons were divided into 3 groups; (A) atomic bomb survivors more than 17 years after exposure, (B) breast-cancer patients during postoperative radiotherapy, and (C) radiation personnel who had been exposed to radiation during a long period of working time. Increased frequencies of aneuploid cells and a number of cells with abnormal chromosomes were observed in most of them, especially in groups A and B. The ratio of hypodiploid cells to hyperdiploid was roughly 1 : 1 in group A and C but 1 : 0.5 in B. From karyotype analysis, rather simple anomalies were often observed in group A but more complicated ones in group B and C. In group A, cells having the same type of abnormalities were observed with higher frequency than expected on a random basis. The difference in radiation conditions and in time lapse after irradiation may account for these differences.