Design of Chiral N-Triflyl Phosphoramide as a Strong Chiral Brønsted Acid and Its Application to Asymmetric Diels−Alder Reaction
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- 6 July 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (30) , 9626-9627
- https://doi.org/10.1021/ja062508t
Abstract
A highly reactive and acidic chiral Brønsted acid catalyst, chiral N-triflyl phosphoramide, was developed. Highly enantioselective Diels−Alder reaction of α,β-unsaturated ketone with silyloxydiene was demonstrated using this chiral Brønsted acid catalyst.Keywords
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