Neuropathology in multiple sclerosis: new concepts
- 1 June 1998
- journal article
- research article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 4 (3) , 93-98
- https://doi.org/10.1177/135245859800400301
Abstract
Multiple sclerosis lesions are characterized by inflammation, demyelination and a variable degree of axonal loss. The patterns of inflammation in MS lesions are compatible with a T-lymphocyte mediated immune reaction. The formation of demyelinated plaques, however, seem to require additional immunological mechanisms. In this review evidence is discussed for a pathogenetic role of demyelinating antibodies, toxic macrophage products, cytotoxic T-cells as well as metabolic disturbances of oligodendrocytes. It is suggested that the pathological heterogeneity regarding the patterns and extent of demyelination, remyelination and axonal loss may be the outcome of variable dominant immunopathogenetic mechanisms in different multiple sclerosis patients.Keywords
This publication has 64 references indexed in Scilit:
- Dying-back oligodendrogliopathy: A late sequel of myelin-associated glycoprotein deficiencyGlia, 1997
- Patterns of oligodendrocyte pathology in coronavirus-induced subacute demyelinating encephalomyelitis in the lewis ratGlia, 1997
- Late Complications of Immune Deviation Therapy in a Nonhuman PrimateScience, 1996
- Glial cell degeneration and hypomyelination caused by overexpression of myelin proteolipid protein geneNeuron, 1994
- Low density lipoprotein uptake by macrophages in multiple sclerosis plaques: implications for pathogenesisNeuropathology and Applied Neurobiology, 1994
- Oligodendrocyte Injury Is an Early Event in Lesions of Multiple SclerosisMayo Clinic Proceedings, 1993
- T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.The Journal of Experimental Medicine, 1992
- Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesionsActa Neuropathologica, 1988
- Multiple sclerosis☆Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different agesJournal of Neuroimmunology, 1983
- The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitisEuropean Journal of Immunology, 1981