Close physical linkage of the murine Ren-1 and Ren-2 loci
Open Access
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (5) , 2111-2126
- https://doi.org/10.1093/nar/16.5.2111
Abstract
In addition to the Ren-1 gene common to all mice, some inbred strains carry a second copy of the renin structural gene, Ren-2. These two loci are tightly linked genetically on mouse chromosome one. We have used pulsed field gel electrophoresis (PFGE) to study the physical arrangement of the two renin genes in the inbred strain DBA/2. PFGE mapping permitted the construction of a restriction map of the Ren loci spanning roughly 120 Kb. The results indicate that the genes are transcribed in the same relative direction, that Ren-2 lies upstream relative to Ren-1, and that the respective coding sequences are separated by approximately 20 Kb.This publication has 37 references indexed in Scilit:
- Megabase-Scale Mapping of the HLA Gene Complex by Pulsed Field Gel ElectrophoresisScience, 1987
- A large inverted duplication allows homologous recombination between chromosomes heterozygous for the proximal t complex inversionCell, 1987
- Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresisNature, 1986
- Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric FieldScience, 1986
- Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresisSomatic Cell and Molecular Genetics, 1986
- Ren-1 and Ren-2 loci are expressed in mouse kidney.Proceedings of the National Academy of Sciences, 1985
- Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions.Molecular and Cellular Biology, 1984
- Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences.Proceedings of the National Academy of Sciences, 1984
- Sequences of Pituitary and Placental Lactogenic and Growth Hormones: Evolution from a Primordial Peptide by Gene ReduplicationProceedings of the National Academy of Sciences, 1971
- ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID .11. FURTHER STUDIES ON NEAREST NEIGHBOR BASE SEQUENCES IN DEOXYRIBONUCLEIC ACIDS1962