The "Gulf War syndrome". Is there evidence of dysfunction in the nervous system?
Open Access
- 1 April 1996
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 60 (4) , 449-451
- https://doi.org/10.1136/jnnp.60.4.449
Abstract
In a pilot study, 14 Gulf War veterans were randomly selected from a large list of those with unexplained illness, to compare the functional integrity of the peripheral and central nervous system with a group of 13 healthy civilian control subjects using predetermined outcome measures. The controls were matched closely for age, sex, handedness, and physical activity. Outcome measures included scoring of symptoms and clinical neurological signs, quantitative sensory testing of heat, cold and vibration sensibilities, motor and sensory nerve conduction studies on upper and lower limbs, needle EMG of distal and proximal muscles and multimodality evoked potential (visual, brainstem, and somatosensory) studies. Three measurements, all related to peripheral nerve function (cold threshold (P = 0.0002), sural nerve latency (P = 0.034), and median nerve sensory action potential (P = 0.030) were abnormal in the veterans compared with the controls. There may be a dysfunction in the veterans but more studies are required to investigate the findings further and to characterise the dysfunction if confirmed.Keywords
This publication has 7 references indexed in Scilit:
- Study of muscular effects of short-term pyridostigmine treatment in resting and exercising ratsHuman & Experimental Toxicology, 1995
- Neurophysiological approaches to the detection of early neurotoxicity in humansCRC Critical Reviews in Toxicology, 1988
- The neurophysiologic investigation of small fiber neuropathiesMuscle & Nerve, 1987
- Myotonic dystrophy. A reassessment by conventional and more recently introduced neurophysiological techniques.1986
- An improved automated method for the measurement of thermal thresholds. 1. Normal subjects.Journal of Neurology, Neurosurgery & Psychiatry, 1985
- Human diabetic endoneurial sorbitol, fructose, and myo‐inositol related to sural nerve morphometryAnnals of Neurology, 1980
- Neurophysiological investigation of subclinical and minimal toxic neuropathiesMuscle & Nerve, 1978