Spontaneous Translocation of a Polymer across a Curved Membrane
- 13 March 1995
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 74 (11) , 2142-2145
- https://doi.org/10.1103/physrevlett.74.2142
Abstract
The translocation of a hydrophobic polymer across a curved bilayer membrane has been studied using Monte Carlo methods. It is found that for curved membranes the polymer crosses spontaneously and almost irreversibly from the side of lower curvature to the side of higher curvature. This phenomenon can be understood based upon the curvature-induced difference of lipid fluctuations between the two halves of the bilayer. The difference of fluctuations drives the polymer across the bilayer in order to maximize the conformational entropy of the polymer.Keywords
This publication has 15 references indexed in Scilit:
- Asymmetries of a curved bilayer model membraneThe Journal of Chemical Physics, 1994
- Spontaneous insertion of polypeptide chains into membranes: a Monte Carlo model.Proceedings of the National Academy of Sciences, 1992
- What drives the translocation of proteins?Proceedings of the National Academy of Sciences, 1992
- The Structure and Insertion of Integral Proteins in MembranesAnnual Review of Cell Biology, 1990
- The nature of the hydrophobic binding of small peptides at the bilayer interface: implications for the insertion of transbilayer helicesBiochemistry, 1989
- Multiple Mechanisms of Protein Insertion into and Across MembranesScience, 1985
- Elastic and flexoelectic aspects of out-of-plane fluctuations in biological and model membranesProgress in Surface Science, 1984
- Thermodynamics and kinetics of protein incorporation into membranes.Proceedings of the National Academy of Sciences, 1983
- The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesisCell, 1981
- Bending Resistance and Chemically Induced Moments in Membrane BilayersBiophysical Journal, 1974