Severe Immobilization Hypercalcemia, Renal Insufficiency, and Calcification

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Abstract
Severe hypercalcemia with decreased renal function, hypertension and renal calcifications developed in 14 yr old boy who required prolonged immobilization for multiple fractures. Parathyroid hormone was not detectable in the serum. Urinary Ca excretion was high. Initially, mobilization was impossible and the patient was treated with a high fluid intake, low Ca intake, acidification of the urine, furosemide and a passive exercise program. Renal function improved and renal calcifications resolved but hypercalcemia did not resolve. After mobilization the serum Ca concentration became normal rapidly. This treatment regimen is suggested for use in patients with immobilization hypercalcemia when mobilization is impossible.

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