Cognitive and molecular aspects of fragile X
- 1 August 1995
- journal article
- research article
- Published by Taylor & Francis in Journal of Clinical and Experimental Neuropsychology
- Vol. 17 (4) , 518-528
- https://doi.org/10.1080/01688639508405142
Abstract
The relationships among parental origin of the fragile X gene, gene structure, and specific cognitive deficits were evaluated in nonretarded adult female fragile X carriers to determine whether: (1) origin influences gene structure and cognitive function, (2) mild cognitive impairments are associated with altered gene structure, and (3) specific cognitive domains are affected. Results indicated that 56% of women with maternally inherited, but none with paternally inherited, fragile X showed large genomic structural alterations and selective deficits on measures of visual attention. Thus, molecular status of the fragile X gene appears to be linked to parental origin and may selectively affect specific cognitive skills.Keywords
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