Clonidine and related analogues. Quantitative correlations
- 1 August 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (8) , 1049-1054
- https://doi.org/10.1021/jm00230a014
Abstract
Twenty-two structural derivatives of clonidine [2-(2,6-dichlorophenylimino)imidazolidine] were synthesized and their main physicochemical parameters determined. Quantitative correlations between the peripheral .alpha.-mimetic action (pithed rats) and physicochemical parameters pointed out the critical role of the steric effect in the ortho positions. Attempted quantitative correlations between physicochemical parameters and central hypotensive activity were unsuccessful. These results are discussed in the light of the postulated mechanism of action of clonidine.This publication has 3 references indexed in Scilit:
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