A CARDIAC ANTI-ARRHYTHMIC SCREENING-TEST IN THE RAT - THE EFFECTS OF LIDOCAINE, PROPRANOLOL AND QUINIDINE

  • 1 January 1980
    • journal article
    • research article
    • Vol. 243  (1) , 97-102
Abstract
The dose-response and time-action parameters for the prototype antiarrhythmic drugs lidocaine, propranolol and quinidine were established using a cardiac antiarrhythmic screening procedure in the rat. This simple screening procedure produces severe cardiac arrhythmias; primarily ventricular fibrillation, in young post-weanling rats which were pretreated with a single i.m. injection of theophylline (20 mg/kg) 15-45 min prior to their inhalation of chloroform vapors.

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