Asymmetric Synthesis of Aryl 2-Piperidyl Methanols from a Chiral α-Aminonitrile Precursor
- 1 June 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (8) , 823-831
- https://doi.org/10.1080/00397918808057851
Abstract
Synthesis of enantiomerically pure phenyl 2-piperidyl methanols from a convenient chiral α-aminonitrile 1 is described. Reaction with aldehydes of the anion generated from 1 leads to threo (αR, 2R) products, whereas treatment of 1 with organolithium reagents affords erythro (αR, 2S) compounds.Keywords
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