Glycosylated Hemoglobin and the Risk of Retinopathy in Insulin-Dependent Diabetes Mellitus
- 11 May 1995
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 332 (19) , 1305-1306
- https://doi.org/10.1056/nejm199505113321915
Abstract
Since we found evidence of a threshold for the effect of hyperglycemia on the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus (IDDM),1 we used published data to examine whether there was a similar pattern for diabetic retinopathy. In the Diabetes Control and Complications Trial (DCCT),2 the incidence of the development or progression of retinopathy in the group assigned to intensive treatment fluctuated around 2.0 per 100 person-years in the nine deciles of the hemoglobin A1c distribution below 8.5 percent and rose to 7.0 per 100 person-years in the highest decile, consistent with a threshold value for hemoglobin A1c of about 8.5 percent.This publication has 5 references indexed in Scilit:
- Glycosylated Hemoglobin and the Risk of Microalbuminuria in Patients with Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1995
- Long-Term Glycemic Control Has a Nonlinear Association to the Frequency of Background Retinopathy in Adolescents With Diabetes: Follow-up of the Berlin Retinopathy StudyDiabetes Care, 1994
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1993
- Risk factors for progression of background retinopathy in long-standing IDDMDiabetes, 1989
- Glycosylated hemoglobin predicts the incidence and progression of diabetic retinopathyJAMA, 1988