PENICILLINASE TREATMENT OF ACUTE RENAL INSUFFICIENCY DUE TO PENICILLIN HYPERSENSITIVITY

5 July 1958

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 167 (10) , 1237-1239
https://doi.org/10.1001/jama.1958.72990270006009a

Abstract

The reported incidence of hypersensitivity reactions to penicillin is variable, but this reaction probably occurs in at least 2% of patients receiving this drug.¹The reaction may assume many forms but usually includes urticaria or some other type of cutaneous eruption. In addition, about half of the patients develop a serum-sickness type of reaction, with fever and joint manifestations. Unusual reactions include purpura and vasculitis. Anaphylactic shock is not infrequently encountered, and many fatal cases are probably not reported. Renal manifestations of hypersensitivity are rarely encountered.²Spring³reported a nephrotic syndrome accompanying a purpuric eruption, and one case of renal shut-down has been reported by Grassi and Catalano⁴in the Italian literature. Of a series of 84 patients with acute renal failure of diverse etiology, one case is attributed to a penicillin reaction, although no details are reported.⁵Our case of penicillin hypersensitivity is unusual

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