Direct 4-Alkylation of 1,3-Cyclohexanediones via Dianionic Species
- 1 January 1986
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1986 (06) , 476-480
- https://doi.org/10.1055/s-1986-31679
Abstract
1,3-Cyclohexanediones are directly alkylated at the 4 position via dianionic species generated at - 78°C using lithium diisopropylamide/hexamethylphosphoric triamide. Acetylation of the reaction products at room temperature yields the 3-acetoxy-6-alkylcyclohex-2-enones selectively.Keywords
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