18-Substituted steroids. Part 8. An improved synthesis of 11β,18,21-trihydroxypregn-4-ene-3,20-dione (‘18-hydroxycorticosterone’)
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 703-705
- https://doi.org/10.1039/p19810000703
Abstract
‘18-Hydroxycorticosterone’(1) has been prepared from 11β-formyloxy-20-hydroxypregn-4-en-3-one (6) by application of the ‘hypoiodite’ series of reactions [Pb(OAc)4–I2–hν; oxidation; solvolysis], followed by acetoxylation at C-21 by lead tetra-acetate in acetic acid. Alkaline hydrolysis then gave 18-hydroxycorticosterone.This publication has 1 reference indexed in Scilit:
- 18-Substituted steroids. Part 5. Further studies on the synthesis of 11β,18,21-trihydroxypregn-4-ene-3,20-dione (‘18-hydroxycorticoster-one’)Journal of the Chemical Society, Perkin Transactions 1, 1980