14α-Hydroxyoestrone, a new oestrogen metabolite

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Abstract
Incubation of estrone with ox adrenal glands leads to the formation of 2 main metabolites, one of which has recently been identified as 15[alpha]-hydroxyestfone; the 2nd metabolite (Oe-5) has now been obtained in crystalline form and identified as the hitherto unknown 14[alpha] -hydroxyestrone. The identity of compound Oe-5 with 14[alpha]-hydroxyestrone was confirmed conclusively by comparison with 14[alpha]-hydroxyestrone that was synthesized by pyrolytic aromatization of 14[alpha]-hydroxyandrosta-l,4-diene-3,17-dione. The physical and chemical properties as well as the estrogenic activity of 14[alpha]-hydroxyestrone are described. The biogenesis and metabolism of 14[alpha]-hydroxyestrone were studied in various tissue preparations.