Pd-Catalyzed Regie- and Stereo-selective Carboxylation of Cycloalkanes with CO
- 1 August 1991
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 20 (8) , 1433-1436
- https://doi.org/10.1246/cl.1991.1433
Abstract
The reactions of cycloalkanes with CO via the C–H bond activation by Pd(OAc)2 catalyst have been found to proceed regio- and stereo-selectively to give corresponding carboxylic acids. The reactivity of C–H bonds of cycloalkanes decreases in the order: tert- > sec- > prim-carbon, and the stereochemistry of the substituents on the main products is all equatorial.Keywords
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