Enantioselective Synthesis of (+)-Isobretonin A
- 1 January 1996
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 61 (13) , 4369-4373
- https://doi.org/10.1021/jo960134o
Abstract
An enantioselective synthesis of (+)-isobretonin A is described. The chiral glycerol moiety was enantioselectively prepared by reduction of an optically active β-keto sulfoxide. The all-trans trienic part of the molecule was stereoselectively synthesized via reductive elimination of a 1,6-dibenzoate 2,4-diene with sodium amalgam.Keywords
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