Transplacental Effects of 1-Ethyl-1-Nitrosourea in Inbred Strains of Mice. III. Association Between Infectious or Subinfectious Endogenous Type-C RNA Tumor Virus Expression and Chemically Induced Tumorigenesis2

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Abstract
We studied the transplacental effects of 1-ethyl-1-nitrosourea (ENU) in strains AKR/J, DBA/2J, SWR/J, C57BL/6J, and C57L/J with respect to possible viralchemical cocarcinogenesis. a) The incidence of type-C RNA viral genome expression, particularly the species-specific, group-specific antigen (gs-AG) increased after transplacental administration of ENU. b) A significant association existed between gs-AG and, in some cases, complete virus expression and chemically induced tumors in mice. However, c) the rate of tumor induction and infectious or subinfectious (gs-AG) viral expression was influenced by the host genotype or strain of mouse. Specifically, d) the induction of tumors by ENU in AKR/J and DBA/2J mice with complete viral expression was accelerated, and e) with the specific oncogenic viral mechanism inherent, but largely unexpressed, in strains SWR/J, C57BL(6J, and C57L/J, ENU induced tumors as wei as gs-AG expression in most mice. Also, f) a previously unrevealed genetic propensity of AKR/J mice for pulmonary tumorigenesis was found with ENU treatment.

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