mSlo , a Complex Mouse Gene Encoding "Maxi" Calcium-Activated Potassium Channels
- 9 July 1993
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 261 (5118) , 221-224
- https://doi.org/10.1126/science.7687074
Abstract
Complementary DNAs (cDNAs) from mSlo , a gene encoding calcium-activated potassium channels, were isolated from mouse brain and skeletal muscle, sequenced, and expressed in Xenopus oocytes. The mSlo -encoded channel resembled "maxi" or BK (high conductance) channel types; single channel conductance was 272 picosiemens with symmetrical potassium concentrations. Whole cell and single channel currents were blocked by charybdotoxin, iberiotoxin, and tetraethylammonium ion. A large number of variant mSlo cDNAs were isolated, indicating that several diverse mammalian BK channel types are produced by a single gene.Keywords
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