Parathyroid hormone response to hypocalcaemia following hypercalcaemia

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Abstract
Experiments were designed to study the ability of Ca infusions to suppress parathyroid hormone (PTH) responses to hypocalcemia, induced by i.v. infusions of ethylene-glycol-bis(.beta.-aminoethylether)N,N''-tetraacetate (EGTA). When plasma Ca was raised for 60 min to levels > 2.6 mmol/l, PTH responses to a subsequent fall of Ca due to EGTA infusions for 7 min were significantly reduced (P < 0.02) or abolished when compared to PTH responses during 7-min EGTA infusions in normocalcemia animals. CaCl2 infusions lasting for only 10 min did not cause a significant reduction of PTH responses to subsequent 7-min EGTA infusions. The results apparently demonstrate that raised Ca reduces PTH available for immedite release. This effect was time-dependent since it was only seen when CaCl2 was infused for more than 10 min prior to the EGTA administration.

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