DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS: ROLE OF MILK ELECTROLYTES
- 1 November 1995
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 22 (s1) , S215-S217
- https://doi.org/10.1111/j.1440-1681.1995.tb02888.x
Abstract
Summary: 1. Milk samples were collected from lactating spontaneously hypertensive rats (SHR) and Wistar‐Kyoto (WKY) normotensive females at 8, 14 or 18 days postpartum.2. Milk samples were later analysed for content of calcium (Ca++), sodium (Na+), potassium (K+), chloride (CI‐) and total protein.3. Milk samples from SHR females had significantly higher concentrations of Na+ (at 8 and 14 days) and CI‐ and significantly lower concentrations of Ca++, K+ (at 8 and 14 days) and total protein compared to milk samples from WKY females.4. Preweanling dietary content of several electrolytes implicated in the development of hypertension differred dramatically between SHR and WKY strains. This altered diet early in life may serve as an environmental trigger for progressive age‐related increases in arterial pressure in SHR.Keywords
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