Pituitary-thyroid function in patients with breast cancer.

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Abstract
The relationship between thyroid function and breast diseases was studied. Neither the mean value of radioiodine uptake rate nor thyroxin (T4) level was significantly different in the patients with benign breast diseases and those with breast cancer or in localized and metastasized cancer groups. As these results were obtained by conventional studies, it became necessary to investigate the dynamic changes of pituitary and thyroid hormones after thyrotopin releasing hormone (TRH [thyroliburin]) stimulation. There were no significant differences in serum thyroid stimulating hormone (TSH), prolactin, tri-iodothyronine (T3) or T4 level before and after TRH stimulation among the benign disease, localized and metastasized cancer groups.