A Comparative Study of Amniotic Fluid, Maternal Sera and Cord Sera by Disc Electrophoresis.

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Abstract
Summary 1) Individual amniotic fluid proteins were quantitated by means of disc elec-trophoresis and immunodiffusion techniques, and proteins of the amniotic fluid were compared to those found in maternal and fetal serum. 2) The findings indicate that the proteins of the amniotic fluid originate at least partly from maternal serum. 3) Selective ultrafiltration on the basis of molecular size cannot explain apparent inhibition of the passage of haptoglobins and IgA into the amniotic fluid. Some additional mechanism, other than simple filtration, must be active. The authors would like to thank Dr. William Flood, Dr. Curtis Flory and members of the Putnam Memorial Hospital delivery room staff for their unfailing help and assistance in obtaining specimens for this study. Gratitude is also expressed to Dr. R. Woodworth of the University of Vermont for supplying purified haptoglobin 1-1.

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