Sensitization capacity of ethylenediamine in the guinea pig and induction of unresponsiveness

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Abstract
The sensitization capacity of ethylenediamine was examined by the guinea pig maximization test and compared with dinitrochlorobenzene [DNCB]. Ethylenediamine was a potent sensitizer. An attempt at oral induction of unresponsiveness (tolerance) was unsuccessful with ethylenediamine and DNCB; the same negative result was obtained with i.v. ethylenediamine. The i.v. injection of dinitrobenzene sulfonic acid allowed establishment of unresponsiveness in 90% of the guinea pigs. [Ethylenediamine has increasingly been the cause of allergic contact dermatitis and it is presently the most frequent human sensitizer in the eastern USA].

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