Synthesis of 1H-4,1,2-benzothiadiazines from substituted N-acetyl-N-aryl-N′-thioaroylhydrazines
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 14,p. 1386-1390
- https://doi.org/10.1039/p19750001386
Abstract
Treatment of N-acetyl-N-aryl-N′-thioaroylhydrazines, in which the N-aryl group is 2,4-disubstituted, with triethylamine in refluxing acetonitrile gives 6-substituted 1-acetyl-3-aryl-1H-4,1,2-benzothiadiazines in cases where the displaceable 2-substituent is bromine, fluorine, or iodine and the 4-substituent is electron-attracting; the synthesis fails when the 2-substituent is chlorine.Keywords
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