Immunologic Response to Lymphocytic Choriomeningitis Virus in Lethally Irradiated Mice Treated With Bone Marrow

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Abstract
Lymphocytic choriomeningitis-immune, nonimmune, and lymphocytic choriomeningitis-carrier mice were exposed to lethal total-body X irradiation and protected by an inoculation of marrow from either immune or nonimmune donors. Subsequent challenge of the surviving chimeras with potent homologous virus established that, under the conditions of these experiments, immunity was a function of the host and not of the transplanted tissue. These observations and those of other workers may be explained by assuming that the preirradiation immunologic response of the chimeras usually persists after irradiation, but that immunologically competent marrow may either react against the host or impose its own immunologic mechanism upon the host.

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