Experimentally induced actinomycotic mycetoma

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Abstract
The ability of Thermoactinomyces vulgaris, T. sacchari and Micromonospora chalcea to produce local actinomycotic mycetoma was compared with that in Actinomyces viscosus and Streptomyces pelletieri. Nodules were produced following subcutaneous or intramuscular injection by all the organisms studied and typical ‘sulphur granules’ were seen histopathologically, when T. vulgaris, M. chalcea, T. sacchari and A. viscosus were involved. All the organisms were sensitive to antibiotics in vitro. In Tierversuchen am Kaninchen wurde die Fähigkeit von Thermoactinomyces vulgaris, T. sacchari und Micromonspora chalcea, lokale Mycetome zu bilden, mit derjenigen von Actinomyces viscosus und Streptomyces pelletieri verglichen. Die subkutane oder intramuskuläre Injektion aller dieser Mikroorganismen führte zur Ausbildung von Knoten; histopathologisch fanden sich bei T. vulgaris, M. chalcea, T. sacchari und A. viscosus typische Drusen. Alle Mikroorganismen zeigten in vitro Sensibilität gegenüber Antibiotica.