Vagal Stimulation of the Heartbeat: Muscarinic Receptor Hypothesis

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Abstract
“For the best and safest method of philosophizing seems to be, first diligently to investigate the properties of things and establish them by experiments, and then later seek hypotheses to explain them… For hypotheses ought to be fitted merely to explain the properties of things and not attempt to predetermine them except so far as they can be an aid to experiments.” (I. Newton, Opera, Vol. IV, p. 314; From The Metaphysical Foundation of Modern Science. E.A. Burtt, Doubleday & Company, Inc., Garden City, New York, 1932; p.215.)