IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes

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Abstract
Since IL-10 has recently been shown to exhibit plelotroplc effects on human monocytes, It was of interest to determine the effect of this cytoklne on prostaglandin E2 (PGEJ production by monocytes. Recomblnant IL-10 (rlL-10) did not significantly affect PGE2 production by lipopolysaccharide (LPS)-unstimulated monocytes, but efficiently inhibited PGE2 production by LPS-stlmulated monocytes. The inhibition by rlL-10 was achieved in a dose-dependent manner. Recombinant IL-4 also inhibited PGE2 production at the same degree as rlL-10. Viral IL-10 Inhibited PGE2 production by monocytes in a similar fashion as did human rlL-10. Endogenously produced IL-10 was also shown to inhibit PGE2 production by LPS-stlmulated monocytes. Kinetic studies showed that the inhibition by rlL-10 on PGE2 production was observed at least 3 h after LPS stimulation. Taken together, these results indicate that IL-10 may play an important role in modulating immunologlcal responses via down-regulation of PGE2 production by monocytes.

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