α‐Latrotoxin receptor
- 28 June 1993
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 325 (1-2) , 81-85
- https://doi.org/10.1016/0014-5793(93)81418-y
Abstract
α-Latrotoxin is a potent stimulator of neurotransmitter release from nerve terminals. High affinity membrane α-latrotoxin receptor was purified in an active binding form. It is a membrane glycoprotein (M r 160,000–220,000) which may be complexed to a smaller polypeptide (M r 29,000). The structure of the receptor protein suggests that it may be a synapse-specific cell recognition molecule. Intracellularly, the α-latrotoxin receptor interacts with synaptotagmin, a calcium- and phospholipid-binding protein specifically localized in the synaptic vesicle membrane. This interaction may be important for targeting of synaptic vesicles to presynaptic release sites.Keywords
This publication has 46 references indexed in Scilit:
- SNAP receptors implicated in vesicle targeting and fusionNature, 1993
- Effect of α‐Latrotoxin on Acetylcholine Release and Intracellular Ca2+ Concentration in Synaptosomes: Na+‐Dependent and Na+‐Independent ComponentsJournal of Neurochemistry, 1993
- Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell linesJournal of Neuro-Oncology, 1993
- Exocytosis and its control at the synapseCurrent Opinion in Neurobiology, 1992
- Acetylcholine Mobilization in a Sympathetic Ganglion in the Presence and Absence of 2‐(4‐Phenylpiperidino)Cyclohexanol (AH5183)Journal of Neurochemistry, 1988
- αLatrotoxin of the black widow spider venom opens a small, non-closing cation channelBiochemical and Biophysical Research Communications, 1986
- Studies on α‐Latrotoxin Receptors in Rat Brain Synaptosomes: Correlation Between Toxin Binding and Stimulation of Transmitter ReleaseJournal of Neurochemistry, 1982
- THE BINDING INTERACTION BETWEEN α‐LATROTOXIN FROM BLACK WIDOW SPIDER VENOM AND A DOG CEREBRAL CORTEX SYNAPTOSOMAL MEMBRANE PREPARATIONJournal of Neurochemistry, 1979
- Freeze-fracture studies of frog neuromuscular junctions during intense release of neurotransmitter. I. Effects of black widow spider venom and Ca2+-free solutions on the structure of the active zone.The Journal of cell biology, 1979
- Purification from black widow spider venom of a protein factor causing the depletion of synaptic vesicles at neuromuscular junctions.The Journal of cell biology, 1976