Induction of the aromatic hydrocarbon receptor by trans-4-acetylaminostilbene in rat liver. Comparison with other aromatic amines
- 1 January 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 8 (7) , 1021-1023
- https://doi.org/10.1093/carcin/8.7.1021
Abstract
The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminopbenanthrene (AAP) and trans-4-acetyl-aminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF and MC did not alter significantly the hepatic receptor concentration. In contrast, the strong liver tumor initiator AAS doubled the hepatic Ah receptor level when a dose of 20 μmol/kg was administered for 5 days. AAP increased the amount of the receptor 1.5-fold.Keywords
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