Immunoproliferative Small Intestinal Disease

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Abstract
THE term "immunoproliferative small intestinal disease" (IPSID) covers a variety of disorders commonly manifested by diarrhea, weight loss, abdominal pain, and clubbing of fingers and toes.1 2 3 4 5 6 The presenting features of the disease are attributed primarily to the presence of diffuse and intense lymphoplasmacytic infiltration of the proximal small intestinal mucosa and mesenteric lymph nodes.1 2 3 4 5 6 7 8 9 10 11 12 The infiltrating cells are variably responsible for synthesizing aberrant alpha-heavy-chain immunoglobulin and forming a matrix for the evolution of primary enteromesenteric lymphoma.2 , 11 12 13 Although IPSID is a rarity of only academic interest in developed countries,14 15 16 it is a prevalent, debilitating illness that afflicts the less prosperous segments . . .