Effects of piretanide in normal subjects

Publisher Website
Google Scholar
Abstract
Piretanide is a new loop diuretic similar to furosemide in pharmacologic properties and approximately 6 times as potent. Oral doses (3-, 6-, and 12-mg) were given to 21 normal subjects and serial blood and urine samples were collected for assessment of the drug''s kinetics and dynamics. There was no evidence for dose-dependent elimination with the doses used. Peak serum concentrations and urinary excretion rates appeared between 30 and 60 min. Elimination t 1/2 [half-life] were 60-90 min. Approximately 45% of a dose was recovered unchanged in the urine. Renal clearance rate was 90-100 ml/min and oral clearance was 200 ml/min. Examination of the relationship between urinary excretion rate of piretanide and Na excretion allowed determination of potency at the tubular level. The piretanide dose that induced half-maximal response was 12.1 .+-. 2.6 .mu.g/min; it is 69.8 .mu.g/min for furosemide and 1 .mu.g/min for bumetanide. Piretanide kinetics resemble those of furosemide and bumetanide, but piretanide is 5 or 6 times as potent as furosemide and 1/10 as potent as bumetanide.