Ibuprofen treatment versus gradual introduction of interferon β-1b in patients with MS
- 1 June 1999
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Neurology
- Vol. 52 (9) , 1893
- https://doi.org/10.1212/wnl.52.9.1893
Abstract
Flu-like symptoms and injection site reactions are adverse effects of treatment with interferon beta-1b in patients with MS. We compared gradual dose escalation, ibuprofen treatment, or their combination in an open-label study. The combination reduced the incidence of flu-like symptoms to rates comparable with the placebo group in the pivotal trial but increased the frequency of injection site reactions, albeit modestly and transiently.Keywords
This publication has 7 references indexed in Scilit:
- Interferon beta‐lb in the treatment of multiple sclerosisNeurology, 1995
- Systemic Recombinant Human Interferon-β Treatment of Relapsing–Remitting Multiple Sclerosis: Pilot Study Analysis and Six-Year Follow-UpJournal of Interferon Research, 1993
- Immune cytokines and regulation of body temperature, food intake and cellular immunityBrain Research Bulletin, 1991
- Effects of interferon-α on the activity of preoptic thermosensitive neurons in tissue slicesBrain Research, 1988
- Approaches to sample size estimation in the design of clinical trials—a reviewStatistics in Medicine, 1984
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983
- Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosisPublished by Elsevier