Identification inin vivoacetylation pathway forN-dealkylated metabolites of doxylamine in humans

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Abstract
1. Metabolites of doxylamine in human urine were separated by g.l.c. and h.p.l.c. and tentatively identified by their mass spectrometric behaviour. 2. N-Desmethyldoxylamine, N, N-didesmethyldoxylamine and their N-acetyl conjugates were identified. This is believed to be the first report of acetylation in vivo of primary and secondary aliphatic amines in man.