Persyn, a Member of the Synuclein Family, Has a Distinct Pattern of Expression in the Developing Nervous System
Open Access
- 15 November 1998
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 18 (22) , 9335-9341
- https://doi.org/10.1523/jneurosci.18-22-09335.1998
Abstract
The synucleins are a unique family of small intracellular proteins that have recently attracted considerable attention because of their involvement in human neurodegenerative diseases. We have cloned a new member of the synuclein family called persyn. In contrast to other synucleins, which are presynaptic proteins of CNS neurons, persyn is a cytosolic protein that is expressed predominantly in the cell bodies and axons of primary sensory neurons, sympathetic neurons, and motoneurons. Northern blotting,in situhybridization, Western blotting, and immunohistochemistry revealed that persyn mRNA and protein are expressed in these neurons from the earliest stages of axonal outgrowth and are maintained at a high level throughout life. Persyn also becomes detectable in evolutionary recent regions of the brain by adulthood.Keywords
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