IgG and IgE Antibody Patterns after Immunotherapy with Monomethoxy Polyethyleneglycol Modified Honey Bee Venom
- 1 February 1986
- Vol. 41 (2) , 89-94
- https://doi.org/10.1111/j.1398-9995.1986.tb00283.x
Abstract
Antibody responses to honey bee venom (HBV) were studied in 13 patients during a 4-month course of immunotherapy with monomethoxy polyethyleneglycol (mPEG) modified venom. There was a rise of HBV-specific IgG antibodies as measured by IgG-RAST in all patients and a slight decrease of IgE antibody in most of them. The IgG-antibody responses during mPEG-HBV treatment as examined by crossed radioimmunoelectrophoresis were directed to phospholipase A, hyaluronidase, acid phosphatase and to another allergen, antigen 1. Thus, despite a high degree of mPEG-modification of HBV, the immunogenicity of the most important HBV allergens was retained.Keywords
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