Serotonin as the hyperglycemic substance released by growth hormone

Publisher Website
Google Scholar
Abstract
Normal dogs were injected (arm vein) with 15 mg/kg body wt of highly purified bovine growth hormone. Forty minutes later 50 ml of blood were removed from the pancreaticoduodenal vein of each animal and immediately injected onto fasting depancreatized dogs. The blood sugar levels of recipient animals were followed at regular intervals for 120 min. A rise in blood sugar was observed, and the hyperglycemic response could be prevented by 2-brom-d-lysergic acid diethylamide, a specific serotonin antagonist. These results suggest strongly that the hyperglycemic substance released into the pancreaticoduodenal venous blood following an injection of growth hormone is serotonin.

This publication has 2 references indexed in Scilit: