Production of Monoclonal Antibodies against Classical Swine Fever Virus and Their Use for Antigenic Characterization of Japanese Isolates.

1 January 1996

journal article
Published by Japanese Society of Veterinary Science in The Journal of Veterinary Medical Science

Vol. 58 (7) , 707-710
https://doi.org/10.1292/jvms.58.707

Abstract

Twenty monoclonal antibodies (MAbs) were produced against the virulent ALD or vaccinal GPE- strains of classical swine fever (CSF) virus. The MAbs were divided into 7 groups on the basis of the difference in the reaction spectrum to various CSF and bovine viral diarrhea-mucosal disease (BVD-MD) viruses. The panel of the MAbs could classify 20 CSF viruses into 6 types, and could discriminate between not only CSF and BVD-MD viruses but also the vaccinal GPE- strain and the field isolates of CSF virus. The results indicated that the MAbs were useful for diagnosis and investigation of CSF viruses.

Keywords

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